Gene Therapy Solutions

Gene Mutations

When human DNA is replicated there is the slight possibility for an error to occur. And while Human DNA has a built-in error-correction mechanism, sometimes this mechanism fails and a copying error is the result. These copying errors are called mutations.

The vast majority of mutations occur in 'junk DNA' and therefore have no effect on a person's well being. When mutations occur in DNA that is used to code proteins, however, physiological effects can occur.

Mutations themselves are relatively rare events. Estimates for the average number of mutations are over 100 per individual and most of those occur in 'junk DNA'. Only a handful of mutations, between one and four, occur in protein-coding DNA. And while this might sound like a lot, given the size of the protein-coding DNA—around 100 million base pairs—mutations are fairly rare events.

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