Identification of tumor-derived mutation (TDM) in liquid biopsies (LB), especially in early-stage patients, faces several challenges, including low variant-allele frequencies, interference by white blood cell (WBC)-derived mutations (WDM), benign somatic mutations and tumor heterogeneity.
Journal:
Cancer Investigation
Publication date:
January 24, 2020
Authors:
Le Son Tran, Quynh-Tho Thi Nguyen, Chu Van Nguyen, Vu-Uyen Tran, Thai-Hoa Thi Nguyen, Ha Thu Le, Mai-Lan Thi Nguyen, Vu Thuong Le, Lam-Son Pham, Binh Thanh Vo , Anh-Thu Huynh Dang, Luan Thanh Nguyen, Thien-Chi Van Nguyen, Hong-Anh Thi Pham, Thanh-Truong Tran, Long Hung Nguyen, Thanh-Thanh Thi Nguyen, Kim-Huong Thi Nguyen, Yen-Vi Vu, Nguyen Huu Nguyen, Vinh-Quang Bui, Hai-Ha Bui, Thanh-Thuy Thi Do, Nien Vinh Lam, Kiet Truong Dinh, Minh-Duy Phan, Hoai-Nghia Nguyen and Hoa Giang
Population-specific profiling of mutations in cancer genes is of critical importance for the understanding of cancer biology in general as well as the establishment of optimal diagnostics and treatment guidelines for that particular population.
Comprehensive profiling of actionable mutations in non-small cell lung cancer (NSCLC) is vital to guide targeted therapy, thereby improving the survival rate of patients.
Journal:
nature.com
Publication date:
February 17, 2020
Authors:
Anh-Thu Huynh Dang, Vu-Uyen Tran, Thanh-Truong Tran, Hong-Anh Thi Pham, Dinh-Thong Le, Lam Nguyen, Ngoc-Vu Nguyen, Thai-Hoa Thi Nguyen, Chu Van Nguyen, Ha Thu Le, Mai-Lan Thi Nguyen, Vu Thuong Le, Phuc Huu Nguyen, Binh Thanh Vo, Hong-Thuy Thi Dao, Luan Thanh Nguyen, Thien-Chi Van Nguyen, Quynh-Tram Nguyen Bui, Long Hung Nguyen, Nguyen Huu Nguyen, Quynh-Tho Thi Nguyen, Truong Xuan Le, Thanh-Thuy Thi Do, Kiet Truong Dinh, …Hoa Giang
The identification and quantification of actionable mutations are of critical importance for effective genotype-directed therapies, prognosis and drug response monitoring in patients with non-small-cell lung cancer (NSCLC).
Journal:
PLOS ONE
Publication date:
December 16, 2019
Authors:
Le Son Tran ,Hong-Anh Thi Pham ,Vu-Uyen Tran ,Thanh-Truong Tran ,Anh-Thu Huynh Dang,Dinh-Thong Le,Son-Lam Nguyen,Ngoc-Vu Nguyen,Trieu-Vu Nguyen,Binh Thanh Vo,Hong-Thuy Thi Dao,Nguyen Huu Nguyen,Tam Huu Tran,Chu Van Nguyen,Phuong Cam Pham,Anh Tuan Dang-Mai,Thien Kim Dinh-Nguyen,Van Hieu Phan,Thanh-Thuy Thi Do,Kiet Truong Dinh,Han Ngoc Do,Minh-Duy Phan,Hoa Giang ,Hoai-Nghia Nguyen