We previously developed a SPOT-MAS assay to capture ctDNA signatures from 05 common cancer types (breast, lung, liver, colorectal, and stomach) and successfully facilitated early-stage detection in both retrospective (1) and prospective validation (2) studies.
The recent study published in Future Oncology, “Evaluation of a Multimodal ctDNA-Based Assay for Detection of Aggressive Cancers Lacking Standard Screening Tests”, extends the analysis to the 05 lethal LSS (lacking standard-of-care screening) cancers: endometrial, esophageal, head and neck, ovarian and pancreatic (3).
The study revealed numerous shared ctDNA signals across 05 common cancers and 05 LSS cancers, demonstrating that SPOT-MAS could detect new lethal cancers with 96.2% specificity and 74.8% overall sensitivity.
This proof-of-concept study shows that SPOT-MAS, a non-invasive test trained on five common cancer types, could detect a number of LSS cancer cases, potentially complementing existing screening programs.
Read the detailed publication summary here: https://spotmas.com/blog/evaluation-of-a-multimodal-ctdna-based-assay-for-detection-of-aggressive-cancers-lacking-standard-screening-tests/
#GeneSolutions #CancerDetection #FutureOncology #SPOTMAS #CancerResearch #EarlyDetection
🔑 References:
(1) Le Son Tran et al. Analytical and clinical validation of a circulating tumor DNA–based assay for multicancer early detection.. JCO 42, 10548-10548(2024).DOI:10.1200/JCO.2024.42.16_suppl.10548
(2) Nguyen, H., Luong, B. A., Tran, D., Nguyen, T., Ngo, Q. D., Le, L. G. H., Ho, Q. C., Nguyen, H. T., Nguyen, C. M., Tran, V. U., Pham, T. V. N., Le, M. T., Le, N. a. T., Le, T. K., Nguyen, T. L., Pham, H. T., Le, H. T., Duong, H. D. T., Hoang, A. V., . . . Tran, D. T. (2021). Ultra-Deep Sequencing of Plasma-Circulating DNA for the Detection of Tumor- Derived Mutations in Patients with Nonmetastatic Colorectal Cancer. Cancer Investigation, 40(4), 354–365. https://doi.org/10.1080/07357907.2021.2017951
(3) Van Thien Nguyen, C., Nguyen, T. H. H., Vo, D. H., Van, T. T. V., Nguyen, G. T. H., Tran, T. H., Nguyen, T. H., Huynh, L. a. K., Nguyen, T. D., Tran, N., Ha, T. M. T., Le, P. T. Q., Truong, X. L., Nguyen, H. L., Tran, U. V., Hoang, T. Q., Nguyen, V. B., Le, V. C., Nguyen, X. C., . . . Tran, L. S. (2024). Evaluation of a multimodal ctDNA-based assay for detection of aggressive cancers lacking standard screening tests. Future Oncology, 1–11. https://doi.org/10.1080/14796694.2024.2413266
